Ah, I think I'm starting to see your problem but I could stil use some more clarification: when you say they don't work, are all the button presses on your X52 not being recongized, are the axes (pitch/roll/throttle) backwards, etc?
Saitek profiles are loaded by the
Saitek profiler software, not by the game. The profiler software works such that a button press on the controller sends a "keypress" to the game, just as if you had pressed that key. A good profile design is based on the default key configuration of the game so you don't need to do any key remapping. You will likely need to set your axes in the game controls, however. I know I have to remap my X52 Pro and CH Pro Rudder pedals for any default config.