I'm running W10 64bit on i5 and GTX1050 without problems. I do not have experienced the red sky bug so far.
A short hint for X52 Problems: Some time ago Saitek
(or parts of it) was taken over by Logitech
. I removed the Saitek
drivers from the system and installed the Logitech
drivers for X52. Since then, I have no further problems with the X52.