Has anyone had trouble running this under Win10? I did the upgrade and tried to run CLOD. It asked my permission to make changes to the PC and briefly flashed that it was trying to install Microsoft VC redist package then the window disappears and it quits loading. No error message. I uninstalled and re-loaded but I get the same thing.

This is a new one on me. I've been running ClOD on win 10 for months now. I recently had a problem after the latest upgrade with windows reassigning joystick axis, but otherwise it's worked okay for me. Maybe you should post over at the ATAG forums if you have not already done so?
Have you tried reinstalling DX? Win 10 uses DX12.
Also, look for windows update KB2670838 in your installed updates and delete it, it's a know crash causer in win 8-10 for ClOD. You don't need it win 10 anyways since it's for IE, which is not supported in win 10.
And make sure you are using windows 10 drivers for your video card.

I think dx is ok - I can run Rise of Flight and Battle of Stalingrad. In fact, this is the first problem since the upgrade. The video card drivers are up to date. I'll try looking up that IE update and see if that helps.

See if anything here is helpful;
http://theairtacticalassaultgroup.com/forum/showthread.php?t=15459
Good luck.

Over on ATAG, someone reported the exact same problem and supposedly installing the TF 3.0 patch cleared it up so I'll give that a try.

CloD "vanila" - the one installed be STEAM with the last official patch (12/2012) don't run in Windows 8/8.1/10 be default.

Is need use the CloDer.exe as Launcher, or better install Team Fusion Patchs, that fix this and a lot more.

CloDER.exe case want try the STEAM version: http://forum.1cpublishing.eu/showthread.php?t=36078

And allow STEAM install the "Redist" package: VCRedist, GDF, DotNet...

Installing TF3.0 fixed it. Installing the rest now.

Ah, I didn't realize that you had not installed the TF patches yet.