Yeah the key layout is similar with the addition of Alt+G for slide, Alt+N for nav points and Alt+A for autonav. I use my regular FS 2 profile on my Cougar for it and it works great.
As for crashing... Post your error message here and here:http://www.hard-light.net/forums/index.php?board=46.0http://wcsaga.com/forum/index.php?f=3&sid=ba1b5d2aef73e253cb8b0f315137a689&rb_v=viewforum
I do notice you have a newer ATI Card, try the following:
"ATI compatibility: Current ATI drivers contain a bug that prevents certain shaders from compiling correctly. Normals maps will not work on ATI HD 4xxx series or older. Solution: install older ATI drivers (mid June 2010), copy atioglxx.dll into the game's directory, and re-install the new ATI drivers. Newer ATI cards should work properly."
Here's an ATI thread here: