Most of the time I find myself using an antimaterial rifle, a Crusher shotgun and a suppressed Overture revolver. With these I can defeat red skull enemies for great loot and lots of experience.

Vehicle wise, I tend to use either a Brennan Apollo motorcycle or a Quadra Type 66 Javelina, as befitting a nomad. The Javelina is one of the fastest vehicles in the game, has AWD and is decently controllable and tough.

Cyberware wise, I think the double jump legs have been of the greatest benefit, they give you a lot of options.