There are three different paths, based on life-choice start, in all of them, you fall foul of the police/corpos/corpos and end up tagging along with Jackie, who partners up with you, and you meet his mum, his gf misty, and they set you up with a new pad...

Then the two mercs V and Jackie are sent by their fixer to find a missing girl. At the site, Jackie suggests you refresh your training with a new shard T-bug had prepared (which you can do, do half of, or skip), then the mission starts.

The speech checks are quite common through the game based on the choice of origin and they open doors/solve problems, but the overall arc is similar from this point on afaict.