I get it too Mark, with little rhyme nor reason to it. Sometimes I have it and sometimes I don't. Sometimes it's a cursor and sometimes the grabby hand thing.
Alt-tab doesn't work for me in RDR 2, but the Windows key does. I can usually make it go away by toggling that a few times, but even that doesn't always work. I've gotten used to, sort of keeping the cursor along the top edge of the screen so that it's more or less out of sight.
I'm rather surprised that no patch has come out yet. It's been eight days since a rocky launch and I expected a few hotfixes straight away.