Welcome to SimHQ!
I would think that unless you are running some of the older sims like Mig Alley,that the vast majority will have no problems running in Win 10.
Off the top of my head,a quick list of sims that I have run in Win 10...
Microsoft Flight Sim X
Flight Sim World
Dovetail Flight School
Rise of Flight
Cliffs of Dover
IL-2 series ('46 and Battle of Stalingrad onwards)
Perhaps if you have a particular list in mind others can help. They may also know of some that won't run under 10.