As a flight simmer, I felt more natural with my
HOTAS + TIR + rudders setup. When I needed to help my son who flies via KB+M, I found it very hard... but he flies perfectly fine so I guess it just depends how used you are to your controls. When you think "yaw right" instead of "left index finger on the . key", that's easier to fly and fight in. So go for whatever's most comfy for you or if you really, really want to, go for what you want to get used to using.