I've been doing a new play through with Misery, and it's brutal!
But after playing for several hours and loading/reloading hundreds of saves; I've found some very annoying things with the mod:
It basically handicaps the player so that it's more challenging; I hate when games do this. Why am I fighting for my life when the rest of the Zone seems to be doing just fine? AI will have infinite ammo, but if you kill them and loot their bodies, 90% of the time they have no ammo. When they do drop ammo, it's usually less then a full mag, and some parts/junk.
Performance - with all of the new items and scripts for each item, when you carry more than ~250 items (bullets included), performance will start to tank. Performance will also drop if you have a ton of items in one of your stash boxes. In a game/mod that focuses on survival and making everything count; it's kind of a pita when you have to sell gear just to get better fps
There are some mods that are based on Misery, but try to balance it out a little better. I just dl'd
Les Miserables , but I haven't tried it yet. It seems a little more down my alley
Overall: Be prepared to get frustrated, and SAVE SAVE SAVE!!!