Do you have a working install patched up to 4.10.1? (Make sure it's not installed to Program Files if you are using Win7 or Vista) If so, make a copy of it. (Copy and paste it.) Now rename it to DWB install or whatever you want. If you are using the downloaded version, install this FIRST http://www.sas1946.com/main/index.php/topic,1531.0.html
before you add anything else. Verify it works. Install UP3 and all updates. Use JSGME and activate UP3. Make sure it works. Deactivate UP3. Install DBW. Run JSGME and activate widescreen and TIR if you have a widescreen and use TIR. Start the selector and make sure that you have DBW selected. Make sure you have the box checked for TIR support. Set your memory usage slider to 1024 (ish) to start out with. Now save settings and try to start it. Don't get frustrated, it's always something simple that's been overlooked. Trust me! I've done it many times!
Other things you might check include making sure the install folder is not set to read only. It sometimes makes it #%&*$#. You might need to run the launcher as an administrator. If you get it to run go here http://www.sas1946.com/main/index.php/topic,19921.0.html
for your one stop easy install for most basic mods. If you use this, you can delete most of the DBW mods in the jsgmemods folder in your install.
Hope it works!