The labels, if allowed by the host, can be switched On/Off by the client (you) with LShift-F10. You will want to turn them off soonest, prolly. IMHO, use the F10 and F7 views a lot, and know your autopilot (AP) modes and use them a lot, too. You'll have your head down flipping switches and stuff so the AP comes in very handy. And get comfortable using the Trim; with a TIR you must reprogram the HOTAS Stick Trim to the actual Trim functions - get the trim right and you won't have to apply constant stick pressure when the AP is off.
It's pretty tough to find targets without the labels or views unless a waypoint is right on top of it, so when you are starting out don't hesitate to take advantage of everything, especially at night
. After a while you will get familiar with the TAD and be able to place the TAD cursor where you want and then switch to the TGP to search the area without the aids. And there are ways to triangulate an RWR threat with the TAD and Mark Points. Other pilots can broadcast their 'SPI' when they have a target to share. Last evening PMike was sending me red triangle target designators over SADL...
I'm making some missions where the labels are allowed. (I'm new to mission making so they are helping me right now.) New pilots can use them, old hands can turn them off. Where the labels are not allowed then you are left to depend on reading the mission briefing carefully. When you don't have anything else to key from, take note of the towns or landmarks near the targets and use those as starting points for your TGP search - like starting a road search from a known bridge. Ask your CIA pals for the target coordinates and plug those into your CDU before you take off and you'll never need a label again. (This is giving me a great idea for another mission.)
The CIA - if you can find them - can tell you the target coordinates. F10 View. Click on a target. F7 View. Copy the coordinates and enter them into your CDU.