I would never use a console controller on a PC game. Mouse and keyboard are is far superior.
Mouse is great. WASD sucks for movement.
WASD sucks even more if you're on a non-Qwerty keyboard. We all have arrow keys, let's use them!
Joystick support? For ME? For WHAT??? I haven't used a joystick for anything but a sim in years.
No joystick support is a real downer for games such as GTA, LA Noire... I want to use a joystick when controlling vehicles in my games. This may not apply to ME3, of course, unless the Mako makes a happy return. You can get by using emulation (making the game believe your joystick is a gamepad), but setting it up can be a lot of fuss.