Another quickie, It's been mentioned that most keyboard/mouse interaction is only necessary for pre fight if you have the Warthog HOTAS but what about communication to the flight group in single player mission/campaigns. As far as I'm aware its a menu of options prefixed with numbers that appears in the top right of the screen. I take it this is another case of having to use the keyboard?
Not if you have
VAC or some other voice command recognition software. Then you just have to speak to the mic... for example, when I am coming in to land, I just dial in the freq of the airfield, key the mic switch, and call inbound. Or for JTAC missions, I just "answer" him back, no need to reach for the mouse. At $18, it is a very cheap way to increase the immersion!
And if you think WC's setup is cool, wait until you see what the others have set up... like one guy with 3x27" monitors and 3x24" touch-screens for panels.

Having said that, most setups are more "wife-friendly" than "uber-cool," lol!
I have a pretty good number of commands set up in my simpit but I still require a mouse for some actions and a keyboard for the stupid radio commands. Really wish I could just click on the radio commands when they appeared on screen instead of having to reach for a keyboard and set in my lap while flying. That's a real PITA!
Again, I would recommend VAC or some similar software, or you could toggle the mouse-click function so you could "click" on the selection with your mouse instead of using the F-kay.