Intel "Ivy Bridge" 22nm desktop CPUs will be released in April. They are the "next big thing". If possible wait until then -- or the Intel system you buy will be out of date only weeks after you put it together.
About the same time, Nvidia will release the new GTX6xx series of 28nm graphics cards. It will be a "whole new ballgame".
In the mean time, as an AMD fan, I would buy AMD stuff. They already have a great 28nm graphics card on the market. And, there will be a higher power one in April to compete with Nvidia

However, for those with the means to wait until April, now is the time to wait. Technology will improve substantially, and prices will drop.
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