I use Avira Free, Malywarebytes and Spybot free.

All are very good. Spybot can scan my system in as little as 7 minutes.

You can try MSE over Avira, but still get Mbam and Spybot.

I've found that running both ESET NOD 4.2 and payed malwarebytes (realtime protection) gives me little hassle and good protection.

Mcafee Stinger is very good at getting rid of those pesky fake anti-virus popups that are so prevalent now.

I'm using Norton 2012 Internet Security, and I can recommend it, well if you use it manually, the automatic mode is pretty good to keep most computer unlegits out of trouble. I have several features turned off though, SONAR sometimes if it makes trouble, and then that browser protection stuff, nothing beats Better Privacy and Adblock plus combined.

Frankly Insight is useless if you're computer savy, it's more a feature for the unknowing, and it often reports mods or other rarer files, as they are not know. I haven't had false alarms safe for some old files, 2012 is less nagging than 2011 though. The Firewall works pretty good, once you've turned it to manual control, though I sometimes meddle with the rules, so the programs only get acces to my computer and not a free pass, to all computers. Configuring them is pretty easy, the port settings are precise and only those needed are opened and only for the program. I know that is standard, but then there have been firewalls that opened ports anything.... It's good if you need one solution for several people with different levels of computer knowledge.

I don't know about the MS SE I've never used them, as I trust MS as far as I can throw an elephant. Also I'm curious about the MSSE calling home to MS. Seems though that they got it right this time.