Dropping back to the older F4 BIOS on the Gigabyte x370 made no difference in performance that I could see or measure (but I did not do a comprehensive test).

In checking, I noticed that Gigabyte has removed the F5 bios from the X370 support page.

Sapphire Pulse RX7900XTX, 3 monitors = 23P (1080p) + SAMSUNG 32" Odyssey Neo G7 1000R curve (4K/2160p) + 23P (1080p), AMD R9-7950X (ARCTIC Liquid Freezer II 420), 64GB RAM@6.0GHz, Gigabyte X670E AORUS MASTER MB, (4x M.2 SSD + 2xSSD + 2xHD) = ~52TB storage, EVGA 1600W PSU, Phanteks Enthoo Pro Full Tower, ASUS RT-AX89X 6000Mbps WiFi router, VKB Gladiator WW2 Stick, Pedals, G.Skill RGB KB, AORUS Thunder M7 Mouse, W11 Pro