I recently tried nGlide when I was recommended to use it for Nuclear Strike.
Its a global wrapper that is installed to Windows. I compared nGlide to DegeVoodoo and this is what I found when testing with NStrike:

nGlide: Higher framerate, no visual artifacts, crashed on level exit only once.
DegeVoodoo: Lower framerate, ground mesh has transparent lines between the polygons, crashed slightly more frequently on level exit.

I will test nGlide with LB2 and see how it works but it would be interesting to see more test-results.
Dont forget to remove glideXX.dll and degevoodoosetup.exe from your LB2 dir before testing.
If degevoodoo is present in LB2 then that will be used regardless if you have nGlide installed or not.